Researchers have found a way to ‘toggle’ the intestinal enzymes responsible for processing starchy foods on and off, which could lead to better control of those processes in people with Type 2 diabetes.

This “toggling” was discovered in the lab of  Simon Fraser University chemist Mario Pinto, who has designed inhibitors capable of regulating each of the four starch-digesting enzymes known as alpha-glucosidases. Three of those enzymes are responsible for generating glucose from starch, each in different ways. A fourth enzyme breaks down sucrose, also giving glucose. Occasionally one or more of the enzymes is missing, which also affects how glucose is created, Pinto explains.



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