Recently, some people subjected themselves to perhaps the most annoying study of 2012; they had to sample and pick the most irritating noises in the world, and they did it for science. 

Researchers used functional magnetic resonance imaging (fMRI) to examine how the brains of 13 volunteers responded to a range of sounds. Listening to the noises inside the scanner they rated them from the most unpleasant to the most pleasing. Scientists were then able to study the brain response to each type of sound and they believe they have found the interaction between the region of the brain that processes sound, the auditory cortex, and the amygdala, which is active in the processing of negative emotions when we hear unpleasant sounds.
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