Antidepressants are the most widely used treatment for people with moderate to severe depression but up to two thirds of people with depression don’t respond fully to antidepressants.

A new paper in The Lancet says cognitive behavioral therapy reduces symptoms of depression and helps improve patient quality of life when provided in addition to the usual care.

They say this is the first large-scale trial to test the effectiveness of cognitive behavioral therapy, a type of talking psychotherapy, given in addition to usual care that includes antidepressants. The CoBalT study aimed to determine the best ‘next step’ treatment for people whose depression had not responded to medication alone. 

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