Blocking a specific protein, ABCC10, renders tumors more vulnerable to treatment in mice

ABCC10 is a type of ATP-binding cassette drug efflux pumps, known more simply as ABC proteins. These proteins sit on the membranes of cells, where they act just like pumps—removing cancer drugs from the cell, thereby making them less effective. The body contains close to 50 such proteins but only 3 appear capable of evading the effects of cancer drugs, including common types used to treat lung, ovarian, and breast cancers.

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