Researchers have identified an enzyme,  PRSS3, specifically linked to aggressive prostate cancer, and have also developed a compound that inhibits the ability of this molecule to promote the metastatic spread of the cancer.

They made the discovery by investigating publicly available databases, derived from clinical studies, which contain data on molecules that are upregulated – irregularly switched on – in cancer. They had previously discovered a link between the protease and the earlier stages of breast cancer. The research team wanted to see if any other cancer abnormally expresses this protease, and at what stages so they mined multiple databases. 

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